AA Amyloidosis: Understanding and Managing a Rare Disorder
Overview
What is AA Amyloidosis?
AA amyloidosis, or secondary amyloidosis, is a rare condition where misfolded proteins accumulate in organs and tissues, leading to organ dysfunction. This typically occurs due to chronic inflammatory conditions or long-lasting infections, which increase serum A protein levels in the bloodstream. Controlling the underlying disease is key to managing AA amyloidosis.
Symptoms and Causes
What Causes AA Amyloidosis?
This condition arises from chronic inflammatory diseases, infections, or inherited periodic fever syndromes. Misfolded proteins form amyloid deposits, commonly affecting the kidneys, liver, and spleen.
Symptoms:
- Swollen feet or legs
- Foamy urine
- Reduced urine output
- Chronic diarrhea
- Enlarged liver or spleen
- Low blood pressure
- Nausea and vomiting
Diagnosis and Tests
Diagnosing AA Amyloidosis:
- Biopsies: Fat pad biopsy (abdominal fat) and organ biopsy.
- Other tests: To differentiate from AL amyloidosis, a more aggressive form.
Management and Treatment
Treating AA Amyloidosis:
- Underlying Condition: Treatment focuses on reducing inflammation from chronic conditions.
- Medications: To manage active amyloidosis and ongoing research into new treatments.
Prevention
Can It Be Prevented?
Prevent AA amyloidosis by treating chronic inflammatory diseases early to manage serum A protein levels.
Outlook / Prognosis
Is It Curable?
Early diagnosis and treatment of the underlying condition can manage and potentially cure AA amyloidosis.
Living With
Self-Care Tips:
Work closely with healthcare providers to manage the underlying inflammatory condition. Understanding the cause and treatment plan is essential for managing AA amyloidosis.
