Table of Contents
Understanding Abiraterone:
Abiraterone operates by reducing the production of androgens in the body, male hormones that can stimulate tumor growth in the prostate gland.
Clinical Application:
Abiraterone, in conjunction with steroid medication (prednisone or methylprednisolone), is utilized to manage prostate cancer that has metastasized. This treatment is employed in men for whom surgery or other medications are not viable options.
Applicability in Women and Children:
The safety and efficacy of abiraterone acetate tablets in females or children are not established.
Important Warnings:
Abiraterone tablets should not be handled by pregnant women or those intending to become pregnant, as it may pose risks to the unborn baby or lead to miscarriage. Individuals allergic to abiraterone should not use it.
Pre-treatment Assessment:
Before commencing abiraterone, it is imperative to inform the doctor about any history of liver disease, diabetes (particularly if using pioglitazone or repaglinide), heart issues, high blood pressure, a prior heart attack, low potassium levels, or adrenal/pituitary gland problems.
Pregnancy and Breastfeeding Considerations:
Abiraterone can harm an unborn baby if a pregnant woman is exposed to it, and precautions are necessary to avoid such exposure. Effective birth control measures are recommended for those with partners who are pregnant or capable of becoming pregnant. Breastfeeding while using abiraterone requires careful consideration and consultation with a doctor.
Administration Guidelines:
Abiraterone should be taken precisely as prescribed, in conjunction with a steroid, following the doctor’s instructions meticulously. Dosage adjustments may occur if there are changes in the brand, strength, or form of the medicine.
Specific Administration Instructions:
- Zytiga is taken on an empty stomach, with no food intake for at least 2 hours before or 1 hour after.
- Yonsa can be taken with or without food.
- The tablet should be swallowed whole, without crushing, chewing, or breaking.
- Regular blood pressure checks and frequent blood tests are essential, especially for those with diabetes.
Dosage Information:
Detailed dosage information for various formulations of abiraterone, depending on the type of prostate cancer, is provided.
Missed Doses and Overdose:
Instructions for missed doses and appropriate actions are outlined. Emergency medical attention is advised in case of an overdose.
Precautions During Treatment:
Guidance is given on avoiding food intake around the time of Zytiga administration, refraining from St. John’s wort supplements, and recognizing potential side effects such as allergic reactions, swelling, irregular heartbeat, and others.
Common Side Effects:
A comprehensive list of common side effects, including weakness, increased blood pressure, joint pain, and cold symptoms, is provided.
Drug Interactions:
The importance of informing the doctor about all current medications is emphasized, with examples of potential interactions listed. Caution is urged, especially with other prostate cancer medicines and specific diabetes medications.
Ingredients:
The active ingredient is abiraterone monohydrate, with specified inactive ingredients listed.
This summary provides comprehensive information about abiraterone, its usage, warnings, administration guidelines, dosage information, and precautions, aiding individuals in understanding and managing their treatment effectively.
